Product Type: Inducer
CAS No.: 25316-40-9
MolecularFormula: C27H29NO11•HCl
Molecular Weight: 580
Source: Synthetic
Purity: >98% (TLC); NMR (Conforms)
Solubility: May be dissolved in water (25 mg/ml); or DMSO (30 mg/ml)
Appearance: Red-Orange powder
PubChem CID: 443939
Scientific Background: Doxorubicin Hydrochloride is used in a clinical setting for the treatment of a wide range of cancers, including lymphomas, leukemias, and solid tumors of the breast, pancreas, stomach, bladder, and ovaries. This drug intercalates into DNA and therefore induces apoptosis by hindering cellular functions like replication and transcription by specifically inhibiting the binding of reverse transcriptase, RNA polymerase and topoisomerase II. Doxorubicin has some adverse effects for patients including immunosuppressive effects caused by hematologic toxicity. Doxorubicin has also been shown to induce autophagy in a species-specific manner.
References: 1. Kusayanagi, T. et al. (2012). Bioorg Med Chem. 20(21): 6248-55.2. Chen, N. T. et al. (2012). PLoS One. 7(9).3. Patel, S. et al. (1997). Mol Pharmacol. 52(4): 658-66.4. Cutts, S. et al. (1996). J Biol Chem. 271(10): 5422-9.5. Danesi, R. et al. (2004). Transplant Proc. 36(3): 703-4.6. Dirks-Naylor, A. (2013). Life Sci. 93(24): 913-6.
Field of Use: Not for use in humans. Not for use in diagnostics or therapeutics. For in vitro research use only.
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