Formulation: Lyophilized from sterile PBS, pH 7.4
Purity: ≥95% estimated by SDS-PAGE
Shelf life (days): 365
Notes: Dipeptidyl peptidase 10 (DPP-10) is a catalytically inactive member of the prolyl oligopeptidase protein family.{65609,65610,65611} It is a type II transmembrane glycoprotein that lacks the serine residue of the catalytic triad essential to the serine protease activity observed in other DPPs.{65609} DPP-10 is expressed at high levels in the brain, pancreas, spinal cord, and adrenal glands, with lower levels in the placenta, liver, and trachea.{65610} Co-expression of DPP-10 with Kv4.2 voltage-gated potassium channels enhances channel currents and accelerates channel inactivation and recovery in Xenopus oocytes. Bronchoalveolar lavage fluid (BALF) levels of DPP-10 are increased in various mouse models of asthma, and serum levels of DPP-10 are increased in patients with NSAID-exacerbated respiratory disease (NERD).{65611} Cayman’s DPP-10 Extracellular Domain (human, recombinant) protein consists of 760 amino acids and has a calculated molecular mass of 87.4 kDa. By SDS-PAGE, under reducing conditions, the apparent molecular mass of the protein is approximately 90-110 kDa due to glycosylation.
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