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Encompassing Amino Acids: 29-end
Applications: Useful for the study of enzyme kinetics, screening inhibitors, and selectivity profiling.
Assay Conditions: 50 mM Tris (pH 7.5), 0.1%BSA, 20 µM substrate (A-P-AMC), room temperature for 10 min.
Background: Dipeptidyl peptidase-4 (DPP4), also known as adenosine deaminasecomplexing protein 2, is a serine exopeptidase that cleaves X-proline dipeptides from theN-terminus of polypeptides. DPP4 plays a key role in glucose metabolism, immuneregulation, signal transduction and apoptosis.
Description: Human DPP4 (GenBank Accession No. NM_001935), a.a. 29-end with C-terminal His-tag, MW=89.1 kDa, expressed in a Baculovirus infected Sf9 cell expression system.
Format: Aqueous buffer solution
Formulation: 45 mM Tris-HCl, pH 8.0,124 mM NaCl, 2.4 mM KCl, 225 mM imidazole,10% glycerol and 3 mM DTT.
Genbank: NM_001935
Storage Stability: At least 6 months at -80°C.
Tags: C-terminal His-tag
Uniprot: P27487
Warnings: Avoid freeze/thaw cycles.
Biosafety Level: Not applicable (BSL-1)
References: 1. Deacon CF, Carr RD, and Holst JJ Front Biosci. 2008 Jan 1;13:1780-94.
2. Langley AK, Suffoletta TJ, and Jennings HRPharmacotherapy. 2007 Aug;27(8):1163-80.Application Reference:Ravassa, S., et al. Cardiovasc Diabetol. 2013 Oct 7;12:143. doi: 10.1186/1475-2840-12-143. The activity of circulating dipeptidyl peptidase-4 is associated with subclinical left ventricular dysfunction in patients with type 2 diabetes mellitus (2013)
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