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Encompassing Amino Acids: 26-end
Applications: Useful for the study of enzyme kinetics, screening inhibitors, and selectivity profiling.
Assay Conditions: 10 mM Tris-HCl, pH 7.4,10 mM MgCl2, 1 mM MnCl2, 20 µM Ala-Pro-AMC,10 min, room temperature.
Background: Dipeptidyl peptidase-7 (DPP7), also known as DPP2, is a serineaminopeptidase found in quiescent lymphocytes. Inhibition of this enzyme inducesapoptosis, and levels of DPP7 are elevated in many tumors, suggesting that DPP7 may beinvolved in a novel pathway for tumor suppression.
Description: Human DPP7 (GenBank Accession No. NM_013379), a.a. 26-end with C-terminal His-tag, MW=52.5 kDa, expressed in a Baculovirus infected Sf9 cell expression system.
Format: Aqueous buffer solution
Formulation: 40 mM Tris-HCl, pH 8.0,110 mM NaCl, 2.2 mM KCl, 220 mM imidazole, and 20% glycerol
Genbank: NM_013379
Storage Stability: At least 6 months at -80°C.
Tags: C-terminal His-tag
Uniprot: Q9UHL4
Warnings: Avoid freeze/thaw cycles.
Biosafety Level: Not applicable (BSL-1)
References: 1. Shreder K.R. et al., Bioorg Med ChemLett. 2005 Oct 1;15(19):4256-60.
2. Maes M.B. et al., Biochem J. 2005 Mar1;386(Pt 2):315-24.