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Encompassing Amino Acids: full length
Applications: Useful for the study of enzyme kinetics, screening inhibitors, and selectivity profiling.
Assay Conditions: 50 mM Tris (pH 7.4),0.1% BSA, 10 µM Ala-Pro-AMC, 10 min.at room temperature.
Background: Dipeptidyl peptidase-8 (DPP8) is a ubiquitously expressed serineexopeptidase that cleaves X-proline dipeptides from the N-terminus of polypeptides.DPP8 shares homology and substrate recognition patterns with DPP4 and like DPP4, isthought to play a role in T-cell activation and immune function.
Description: Human DPP8 (Dipeptidylpeptidase 8), GenBank Accession No. NM_197960, full length with N-terminal GST-tag, MW=129.3 kDa, expressed in a Baculovirus infected Sf9 cell expression system.
Format: Aqueous buffer solution
Formulation: 45 mM Tris-HCl, pH 8.0,124 mM NaCl, 2.4 mM KCl, 18 mM Glutathione,10% glycerol, and 3 mM DTT.
Genbank: NM_197960
Storage Stability: At least 6 months at -80°C.
Tags: N-terminal GST-tag
Uniprot: Q6V1X1
Warnings: Avoid freeze/thaw cycles.
Biosafety Level: Not applicable (BSL-1)
References: 1. Lee, H.J. et al., J. Biol. Chem. 281 (50),38653-38662 (2006).
2. Yu, D.M. et al., FEBS J. 273 (11), 2447-2460(2006).