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Encompassing Amino Acids: 25-199
Application: Useful for binding studies and inhibitors of binding.
Assay Conditions: Assay was done according to DR3:TL1A Inhibitor Screening Assay Kit (#82241). Increasing amounts of DR3 were coated on a plate, and TL1A, His-Tag, Avi-Tag, Biotin-Labeled Recombinant (#101882) was used as binding partner.
Background: DR3 (death receptor 3), also known as tumor necrosis factor receptor superfamily member 25 or TNFRSF25, is a membrane receptor of the tumor necrosis factor receptor superfamily of proteins (TNFRSF), which associates with TL1A (TNF-like protein 1A) in T and NK cells. DR3 has been recognized as a significant anti-apoptotic and differentiation factor and it is a co-stimulatory receptor. TL1A, also called TNFSF15, is a member of the tumor necrosis factor family. It is expressed in different immune cells, such as monocyte, macrophage, dendritic cell, T cell and non-immune cells. TL1A competitively binds to DR3, having a higher affinity for DcR3 (decoy receptor 3), providing stimulatory signal for downstream signaling pathways. It then regulates proliferation, activation, apoptosis, and chemokine production in effector cells. The role of DR3 in T cell activation, and consequently in cytokine secretion and cell proliferation, makes it an attractive target in cancer therapy. Inhibition of DR3-TL1A interaction has substantial therapeutic potential in the treatment of solid tumors.
Description: Recombinant human DR3 (death receptor 3), encompassing amino acids 25-199. This construct contains a C-terminal His-tag (10xHis). This protein was affinity purified.
Format: Aqueous buffer solution.
Formulation: 10 mM phosphate pH 7.4, 138 mM NaCl, and 2.7 mM KCl
Genbank: NM_003790.3
Purity: ≥90%
Supplied As: At least 6 months at -80°C.
Tags: Tumor necrosis factor receptor superfamily member 25, Apo-3, Apoptosis-inducing receptor AIR, Apoptosis-mediating receptor DR3, Apoptosis-mediating receptor TRAMP, Death receptor 3, TNFRSF25, APO3, DDR3, DR3, TNFRSF12, WSL, WSL1
Target: C-terminal His-Tag
Uniprot: Q93038
Warnings: Avoid multiple freeze/thaw cycles.
Biosafety Level: Not applicable (BSL-1)
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