Formulation: A solid
Formal Name: α-[(9R)-6-hydroxy-6-oxido-1,12-dioxo-9-[(1-oxooctadecyl)oxy]-5,7,11-trioxa-2-aza-6-phosphanonacos-1-yl]-ω-[2-[(4,6-dichloro-1,3,5-triazin-2-yl)amino]ethoxy]-poly(oxy-1,2-ethanediyl), monoammonium salt
Purity: ≥90%
Formula Markup: (C2H4O)nC47H85Cl2N5O10P • NH4
CAS Number: 1246304-74-4
Notes: DSPE-PEG(2000) Cyanur is a PEGylated form of 1,2-distearoyl-sn-glycero-3-PE (DSPE; Item No. 15095) that has been used in the generation of lipid nanoparticles (LNPs) for the delivery of micro RNA (miRNA) in vitro.{51713} LNPs containing DSPE-PEG(2000) cyanur, encapsulating let-7a miRNA, and conjugated to the Eph tyrosine kinase receptor (Eph) ligand ephrin-A1 reduce the proliferation and colony formation and size of NCI H2081, NCI 5380, and A549 lung cancer cells, as well as reduce migration of NCI 5380 cells in a wound healing assay.
English
Deutsch
