Products from BPS Bioscience require a minimum order value above 400€
Applications: Study enzyme kinetics and screen small molecular inhibitors for drug discovery and high throughput (HTS) applications.
Background: DYRK2 (dual specificity tyrosine phosphorylation regulated kinase 2) is a serine/threonine kinase as well as a tyrosine kinase implicated in the control of cell proliferation, cell cycle progression, and cytoskeleton organization. DYRK2 has demonstrated tyrosine autophosphorylation activity. It is notably activated by ATM in response to DNA damage and phosphorylates serine 46 on tumor suppressor TP53, leading to apoptosis. Many other targets have been identified, including various ligases involved in ubiquitination and ubiquitin-dependent proteasomal degradation of proteins. The kinase indisputably plays a role in various types of cancer, although its exact function and mechanism of action in cancer cells remains somewhat elusive.
Contraindications: The final concentration of DMSO in the assay should not exceed 1%.
Description: The DYRK2 Kinase Assay Kit is designed to measure DYRK2 kinase activity for screening and profiling applications using Kinase-Glo® MAX as a detection reagent.
Storage Stability: This assay kit will perform optimally for up to 6 months from date of receipt when the materials are stored as directed.
Supplied As: The assay kit comes in a convenient 96-well format, with enough purified recombinant DYRK2 kinase, kinase substrate, ATP, and kinase assay buffer for 100 enzyme reactions.
Uniprot: Q92630
Warnings: Avoid freeze/thaw cycles.
Biosafety Level: Not applicable (BSL-1)
English
Deutsch
