Clone Name: Dy8/6C5
Application Note: IHC-Fr: 1:20. *Optimal dilutions/concentrations should be determined by the researcher.Not tested in other applications.
Calculated MW: 427
Specificity/Sensitivity: This antibody reacts strongly with the carboxy terminus (between amino acids 3669 and 3685) of human dystrophin.No cross-reactivity with mdx mouse tissue. Cross reacts very weakly with pig dystrophin.
Form: Liquid
Buffer (with preservative): Tissue culture supernatant, 0.09% Sodium azide.
Concentration:
Background: This gene spans a genomic range of greater than 2 Mb and encodes a large protein containing an N-terminal actin-binding domain and multiple spectrin repeats. The encoded protein forms a component of the dystrophin-glycoprotein complex (DGC), which bridges the inner cytoskeleton and the extracellular matrix. Deletions, duplications, and point mutations at this gene locus may cause Duchenne muscular dystrophy (DMD), Becker muscular dystrophy (BMD), or cardiomyopathy. Alternative promoter usage and alternative splicing result in numerous distinct transcript variants and protein isoforms for this gene. [provided by RefSeq, Dec 2016]
Uniprot ID: P11532
Antigen Species: Human
Immunogen: Synthetic polypeptide consisting of the last 17 amino acids at the carboxy terminus of the human dystrophin sequence.
Purification: Unpurified
Conjugation: Unconjugated
Full Name: dystrophin
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