DZD9008, CAS 2370013-49-1

Formulation: A solid

Formal Name: N-[5-[[4-[[5-chloro-4-fluoro-2-(1-hydroxy-1-methylethyl)phenyl]amino]-2-pyrimidinyl]amino]-2-[(3S)-3-(dimethylamino)-1-pyrrolidinyl]-4-methoxyphenyl]-2-propenamide

Purity: ≥95%

Formula Markup: C29H35ClFN7O3

Formula Weight: 584,1

Shelf life (days): 1460

CAS Number: 2370013-49-1

Notes: DZD9008 is an irreversible inhibitor of EGFR containing a lysine-to-arginine mutation at position 858 and T790M (EGFRL858R,T790M; IC50 = 1.1 nM).{68618} It is selective for EGFRL858R,T790M over Bruton's tyrosine kinase (BTK), wild-type EGFR, focal adhesion kinase (FAK), HER2, and HER4 (IC50s = 213, 226, 255, 392, and 704 nM, respectively) but also inhibits wild-type EGFR containing an exon 19 deletion, EGFRT790M containing an exon 19 deletion, EGFRL585R, EGFRG192A, and EGFRL861Q (IC50s = 1.3-12 nM). DZD9008 (25 and 50 mg/kg twice per day) reduces tumor volume in a patient-derived xenograft (PDX) mouse model of non-small cell lung cancer (NSCLC).

• SKU: CAY38900-5
• Manufacturer: Cayman Chemical
• Manufacturer SKU: 38900-5
• Green Labware: No
• Package Unit: 5 mg
• Quantity Unit: STK