Formulation: A solid
Formal Name: (11β,17β)-11-(4-cyclopropylphenyl)-17-(1,1-difluoro-2-propyn-1-yl)-17-hydroxy-estra-4,9-dien-3-one
Purity: ≥98%
Formula Markup: C30H32F2O2
Formula Weight: 462,6
Shelf life (days): 1460
CAS Number: 2016795-77-8
Notes: EC330 is an inhibitor of leukemia inhibitory factor (LIF) activity.{72184} It binds to the LIF receptor (LIFR) and is selectively cytotoxic to MCF-7 cells ectopically overexpressing LIF (IC50 = 0.075 µM) over non-LIF-overexpressing MCF-7 cells (IC50 = 0.245 µM). EC330 reduces ectopic LIF expression-induced increases in the migration of MCF-7 and MDA-MB-231 cells when used at concentrations of 5 and 15 nM, respectively. It also induces ferroptosis in 293T and 786-O cells and reduces the levels of glutathione (GSH) and the intracellular activity of glutathione peroxidase (GPX) in vitro.{72185} EC330 (1 mg/kg) reduces tumor burden to a greater extent in a mouse xenograft model using MDA-MB-231 cells with ectopic LIF expression than when using MDA-MB-231 cells without ectopic LIF expression.{72184}
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