EG01377 (dihydrochloride), CAS 2749438-61-5

Product Description: EG01377 dihydrochloride is a potent, bioavailable and selective inhibitor of neuropilin-1 (NRP1), with a Kd of 1.32 μM, and IC50s of 609 nM for both NRP1-a1 and NRP1-b1. EG01377 dihydrochloride has antiangiogenic, antimigratory, and antitumor effects[1].

Applications: Cancer-Kinase/protease

Formula: C26H32Cl2N6O6S2

References: [1]Powell J, et al. Small Molecule Neuropilin-1 Antagonists Combine Antiangiogenic and Antitumor Activity with Immune Modulation through Reduction of Transforming Growth Factor Beta (TGFβ) Production in Regulatory T-Cells. J Med Chem. 2018 May 10;61(9):4135-4154.

CAS Number: 2749438-61-5

Molecular Weight: 659.60

Compound Purity: 98.98

Research Area: Cancer

Solubility: DMSO : 200 mg/mL (ultrasonic)

Target: Complement System

• SKU: MEXHY-112151A-10
• Manufacturer: MedChemExpress
• Manufacturer SKU: HY-112151A-10
• Package Unit: 10 mg
• Quantity Unit: STK