Formulation: A solution in ethanol
Formal Name: 5Z,8Z,11Z,14Z,17Z-eicosapentaenoic-19,19,20,20,20-d5 acid, ethyl ester
Purity: ≥99% deuterated forms (d1-d5)
Formula Markup: C22H29D5O2
Formula Weight: 335,5
Shelf life (days): 365
CAS Number: 2483831-19-0
Notes: Eicosapentaenoic acid-d5 ethyl ester is intended for use as an internal standard for the quantification of eicosapentaenoic acid ethyl ester (Item No. 10008884) by GC- or LC-MS. Eicosapentaenoic acid (EPA) ethyl ester is an esterified form of the ω-3 fatty acid EPA (Item Nos. 90110 / 90110.1 / 21908). Dietary administration of EPA ethyl ester (41.4 g/100 g of total dietary fatty acids) increases the ex vivo activity of hepatic β-oxidation enzymes.{16514,16499} It also reduces total hepatic triglyceride levels and increases the ω-3 fatty acid content of hepatic triglycerides and phospholipids, as well as increases the total levels of ω-3 fatty acids in rats. EPA ethyl ester (1 g/kg) reverses increases in plasma cholesterol levels and reduces circulating triglyceride levels in rats fed a high-fat diet.{16497} Formulations containing eicosapentaenoic acid ethyl ester have been used as adjuncts in the treatment of hypertriglyceridemia.
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