Target: PDI
Conjugate: FITC
Product Type: Monoclonal
Clone Number: 2E7/7
Immunogen: Synthesized peptide - 12 amino acids long (ADGEDGQDPHSK) corresponding to residues 52 - 63 of the Human EndoPDI protein
Swiss-Prot: Q8NBS9
Purification: Protein G Purified
Storage Buffer: PBS pH7.4, 50% glycerol, 0.09% sodium azide *Storage buffer may change when conjugated
Concentration: 1 mg/ml
Specificity: Detects ~48kDa.
Cellular Localization: Endoplasmic Reticulum,Endoplasmic Reticulum Lumen
Scientific Background: Endothelial protein disulfide isomerase (EndoPDI) is a thioredoxin member of the protein disulfide isomerase family of chaperones. This enzyme has been localized to the endoplasmic reticulum in primary endothelial cells, but colocalizes with nucleoli in the nuclei of breast, colon, and renal cancer cells. EndoPDI mRNA and protein expression is induced by hypoxia and exhibits a protective effect on endothelial cells during hypoxia (1).
References: 1. Sullivan D.C., et al. (2003) J Biol Chem. 278 (47) 47079-47088.
Field of Use: Not for use in humans. Not for use in diagnostics or therapeutics. For in vitro research use only.
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