Formulation: 500 µl of peptide affinity-purified polyclonal antibody
Immunogen: Synthetic peptide from an internal region of human EP3 receptor
Shelf life (days): 1095
Notes: The biological effects of prostaglandin E2 (PGE2) are mediated through interaction with four distinct membrane-bound G-protein coupled EP receptors: EP1, EP2, EP3, and EP4.{6742,9114} As a result of splice variation, the EP3 receptor can be expressed as multiple isoforms that differ in the length and sequence of their C-terminal tails.{9114,3180} The signal transduction mechanism varies depending on the isoform being expressed, implicating the importance of the C-terminal region of the receptor for coupling to G-proteins.{9114,3180} The EP3 receptor is expressed in a variety of tissues with highest levels in kidney, pancreas, and uterus.{3180,1610,3179}
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