EP4 receptor antagonist 1, CAS 2287259-07-6

Product Description: EP4 receptor antagonist 1 is a highly potent and selective competitive prostanoid EP4 receptor antagonist for cancer immunotherapy. EP4 receptor antagonist 1 inhibits human and mouse EP4 receptor with IC50s of 6.1 nM and 16.2 nM, respectively. IC50s >10 μM for human EP1, EP2,and EP3 receptors[1].

Applications: COVID-19-immunoregulation

Formula: C23H21F3N4O3

References: [1]Yang JJ, et al. Discovery and Characterization of 1H-1,2,3-Triazole Derivatives as Novel Prostanoid EP4 Receptor Antagonists for Cancer Immunotherapy. J Med Chem. 2020 Jan 23;63(2):569-590.

CAS Number: 2287259-07-6

Molecular Weight: 458.43

Compound Purity: 99.66

Research Area: Cancer; Inflammation/Immunology

Solubility: DMSO : 100 mg/mL (ultrasonic)

Target: Prostaglandin Receptor

• SKU: MEXHY-133123-10.1
• Manufacturer: MedChemExpress
• Manufacturer SKU: HY-133123-10.1
• Package Unit: 10mM/1mL
• Quantity Unit: STK