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Applications: Study enzyme kinetics and screen small molecular inhibitors for drug discovery and high throughput (HTS) applications.
Background: EPH receptor A4 (EPHA4), belongs to the ephrin receptor subfamily of protein-tyrosine kinases which have been implicated in mediating developmental events, particularly in the nervous system. The EPHA4 ligand ephrin-A3 is localized to the astrocytic processes that envelop the spine. Activation of EPHA4 by ephrin-A3 induces spinal retraction, reduces spine density, and inhibits the interaction distorted spine shape and organization. EPHA4-null mice possess defects in the corticospinal tract and anterior commissure indicating a model in which an ephrin ligand on the axons senses EPHA4 on spinal cord cells surrounding the corticospinal tract.
Description: The EPHA4 Kinase Assay Kit is designed to measure EPHA4 kinase activity for screening and profiling applications using ADP-Glo® as a detection reagent.
Storage Stability: This assay kit will perform optimally for up to 6 months from date of receipt when the materials are stored as directed
Supplied As: The assay kit comes in a convenient 96-well format, with enough purified recombinant EPHA4 kinase, kinase substrate, ATP and kinase assay buffer for 100 enzyme reactions.
Uniprot: P54764
Warnings: Avoid freeze/thaw cycles
Biosafety Level: Not applicable (BSL-1)
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