Product Type: Inducer
CAS No.: 152044-54-7
MolecularFormula: C27H41NO6S
Molecular Weight: 507,68
Source: Synthetic
Purity: >98%
Solubility: Soluble to 10 mM in DMSO
Appearance: White Solid
PubChem CID: 448013
Scientific Background: Epothilone are a new class of cancer drugs. They prevent cancer cells from dividing by interfering with tubulin (1). Epithilone B possess the same biological effects as paclitaxel in both invitro and cultured cells, because they share the same binding site (2). Epothilone has also been shown to induce tubulin polymerization into microtubules without the presence of GTP. And it also causes cell cycle arrest at the G2-M transition phase, leading to eventual cell apoptosis (3).
References: 1. Rosenberg S., Devita V.T., Hellman S. (2005) Cancer: Principles & Practice of Oncology: Lippincott Williams and Wilkins.2. Julien B., Shah S. (2002) Antimicrob Agents Chemother. 46(9): 2772.3. Balog D.M., et al. (1996) Angew Chem. 108: 2976.
Field of Use: Not for use in humans. Not for use in diagnostics or therapeutics. For in vitro research use only.
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