Product Type: Inhibitor
CAS No.: 134381-21-8
MolecularFormula: C28H50N4O7
Molecular Weight: 554,7
Source: Synthetic
Purity: >95%
Solubility: Soluble in DMSO (15 mg/ml) or dichloromethane:methanol (9:1); insoluble in water.
Appearance: White solid
PubChem CID: 11226684
Scientific Background: Epoxomicin is a cell permeable, potent and selective proteasome inhibitor originally isolated from Actinomycetes strain based on its potent in vivo antitumor activity. It is a more potent inhibitor of the chymotrypsin-like activity of the proteasome than lactacystin. Epoxomicin also blocks trypsin-like and PGPH activities of the proteasome and regulates antigen presentation at non-toxic doses. It effectively inhibits NF-κB activation in vitro and potently blocks inflammation in vivo in the mouse ear edema assay. The ubiquitin-proteasome system (UPS) and autophagy serve as two complementary, reciprocally regulated protein degradation systems, thus inhibition of UPS by Epoxomicin activates autophagy.
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Field of Use: Not for use in humans. Not for use in diagnostics or therapeutics. For in vitro research use only.