Abbreviation: ERCC6
Target Synonym: CSB;CKN2;COFS;ARMD5;COFS1;POF11;RAD26;UVSS1;CSB-PGBD3;ERCC6
Conjugation: Unconjugated
UNIProt ID: Q03468
Background: This gene encodes a DNA-binding protein that is important in transcription-coupled excision repair. The encoded protein has ATP-stimulated ATPase activity, interacts with several transcription and excision repair proteins, and may promote complex formation at DNA repair sites. Mutations in this gene are associated with Cockayne syndrome type B and cerebrooculofacioskeletal syndrome 1. Alternative splicing occurs between a splice site from exon 5 of this gene to the 3' splice site upstream of the open reading frame (ORF) of the adjacent gene, piggyback-derived-3 (GeneID:267004), which activates the alternative polyadenylation site downstream of the piggyback-derived-3 ORF. The resulting transcripts encode a fusion protein that shares sequence with the product of each individual gene.
Concentration: 1mg/mL
Immunogen: A synthetic peptide of human ERCC6
Dilution: WB 1:500-1:2000,IHC 1:50-1:200
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