Application Note: WB: 1:500-1:2000. *Optimal dilutions/concentrations should be determined by the researcher.Not tested in other applications.
Calculated MW: 52
Form: Liquid
Buffer (with preservative): Filter-sterilized PBS, no preservative.
Concentration: Batch dependent (Please refer to the vial label for the specific concentration.)
Background: This gene encodes vitamin K-dependent coagulation factor IX that circulates in the blood as an inactive zymogen. This factor is converted to an active form by factor XIa, which excises the activation peptide and thus generates a heavy chain and a light chain held together by one or more disulfide bonds. The role of this activated factor IX in the blood coagulation cascade is to activate factor X to its active form through interactions with Ca+2 ions, membrane phospholipids, and factor VIII. Alterations of this gene, including point mutations, insertions and deletions, cause factor IX deficiency, which is a recessive X-linked disorder, also called hemophilia B or Christmas disease. Alternative splicing results in multiple transcript variants encoding different isoforms that may undergo similar proteolytic processing. [provided by RefSeq, Sep 2015]
Uniprot ID: P00740
Antigen Species: Human
Immunogen: Recombinant Human Factor IX protein (GTX01255-pro)
Purification: Purified by Protein A and Antigen Affinity
Conjugation: Unconjugated
Full Name: coagulation factor IX
English
Deutsch
