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Encompassing Amino Acids: 2791-2911
Applications: Useful for the study of bromodomain binding assays, screening inhibitors, and selectivity profiling.
Background: FALZ is a bromodomain-containing protein that is the histone-binding component of NURF (nucleosome-remodeling factor), a complex which catalyzes ATP-dependent nucleosome sliding and facilitates transcription of chromatin. Specifically recognizes H3 tails trimethylated on Lys4 (H3K4me3), which mark transcription start sites of virtually all active genes. May also regulate transcription through direct binding to DNA or transcription factors. High levels of FALZ were detected in fetal brain and in patients with neurodegenerative diseases.
Description: Human Fetal Alzheimer Antigen (FALZ), also known as Fetal Alz-50 Clone 1 Protein or bromodomain PHD finger transcription factor (BPTF), GenBank Accession No. NM_182641, a.a. 2791-2911 corresponding to single bromodomain, with N-terminal GST-tag, MW=41 kDa, expressed in an E. coli cell expression system.
Format: Aqueous buffer solution
Formulation: 40 mM Tris-HCl, pH 8, 110 mM NaCl, 2.2 mM KCl, 0.04% Tween-20, and 20% glycerol.
Genbank: NM_182641
Storage Stability: Store at -80°C. Stable for >6 months when stored as directed.
Tags: N-terminal GST-tag
Uniprot: Q12830
Warnings: Avoid freeze/thaw cycles.
Biosafety Level: Not applicable (BSL-1)
References: 1. Buganim, Y., et al.,Structure. PLoS One. 2010;11;5(3):e9657.
2. Ruthenburg, A.J., et al., Cell. 2011;145(5):692-706.
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