FALZ (BPTF), His-tag Recombinant

FALZ (BPTF), His-tag Recombinant
SKU
BPS31131
Packaging Unit
100 µg
Manufacturer
BPS Bioscience

Availability: loading...
Price is loading...
Products from BPS Bioscience require a minimum order value above 400€

Encompassing Amino Acids: 2791-2911

Applications: Useful for the study of bromodomain binding assays, screening inhibitors, and selectivity profiling.

Background: FALZ is a bromodomain-containing protein that is the histone-binding component of NURF (nucleosome-remodeling factor), a complex which catalyzes ATP-dependent nucleosome sliding and facilitates transcription of chromatin. Specifically recognizes H3 tails trimethylated on Lys4 (H3K4me3), which mark transcription start sites of virtually all active genes. May also regulate transcription through direct binding to DNA or transcription factors. High levels of FALZ were detected in fetal brain and in patients with neurodegenerative diseases.

Description: Human Fetal Alzheimer Antigen (FALZ), lso known as Fetal Alz-50 Clone 1 Protein or bromodomain PHD finger transcription factor (BPTF), GenBank Accession No. NM_182641, a.a. 2791-2911 corresponding to single bromodomain, with N-terminal His-tag, MW=15.2 kDa, expressed in an E. coli expression system.

Format: Aqueous buffer solution

Formulation: 45 mM Tris-HCl, pH 8.0, 124 mM NaCl, 2.4 mM KCl, 225 mM imidazole, 3 mM DTT, and 10% glycerol.

Genbank: NM_182641

Storage Stability: At least 6 months at -80°C.

Tags: N-terminal His-tag

Uniprot: Q12830

Warnings: Avoid freeze/thaw cycles.

Biosafety Level: Not applicable (BSL-1)

References: 1. Buganim, Y., et al.,Structure. PLoS One. 2010;11;5(3):e9657.
2. Ruthenburg, A.J., et al., Cell. 2011;145(5):692-706.
More Information
SKU BPS31131
Manufacturer BPS Bioscience
Manufacturer SKU 31131
Green Labware No
Package Unit 100 µg
Quantity Unit STK
Product information (PDF) Download
MSDS (PDF)
×