Product Type: Inhibitor
CAS No.: 103745-39-7
MolecularFormula: C14H17N3O2S•HCl
Molecular Weight: 327,83
Source: Synthetic
Purity: ≥98% (TLC); NMR (Conforms)
Solubility: May be dissolved in DMSO (75 mg/ml) or water (100 mg/ml)
Appearance: Powder
PubChem CID: 3547
Scientific Background: Fasudil is a ROCK2 inhibitor with some action on PRK2 and MSK1 (IC50 values are 1.9 µM, 4 µM and 5 µM respectively). It is also shown to inhibit RSK1, RSK2, PKA, AMPK and PKd1. It is also a calcium channel antagonist and vasodilator.
References: 1. Shirotani M., et al. (1991) J. Pharmacol. Exp. Ther. 259(2): 738-744.2. Arai M., Nozawa R., et al. (1993) Biochem. Pharmacol. 46(8): 1487-1490.3. Satoh S., et al. (1996) Br. J. Pharmacol. 118(7): 1592-1606.4. Sward K., et al. (2000) J. Physiol. 522: 33-49.
Field of Use: Not for use in humans. Not for use in diagnostics or therapeutics. For in vitro research use only.
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