FcRL5/Firefly Luciferase RPMI 8226 Cell Line

FcRL5/Firefly Luciferase RPMI 8226 Cell Line
SKU
BPS78378
Packaging Unit
2 vials
Manufacturer
BPS Bioscience

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Applications: Use as target cells for anti-FcRL5 CAR T cells, anti-FcRL5 ADC, and bi-specific antibodies.

Background: FcRL5 is a single-pass type 1 membrane protein which contains 8 immunoglobulin-like C2-type domains. FcRL5 may be involved in B cell development and lymphomagenesis. Moreover, it is enriched in malignant plasma cells of patients diagnosed with multiple myeloma, and is an attractive target for antibody-drug conjugates (ADC) and anti-FcRL5 CAR T cells. RPMI 8226 cells are human B cells isolated from a plasmacytoma/myeloma patient.

Description: Recombinant RPMI 8226 cells constitutively expressing firefly (Photinus pyralis) luciferase (BPS Bioscience #79834) have also been engineered to constitutively express the full length human FcRL5 (Fc Receptor Like 5, also known as CD307, ref. seq. NM_031281).

Host Cell Line: RPMI 8226

Mycoplasma Testing: The cell line has been screened to confirm the absence of Mycoplasma species.

Storage Stability: Cells are shipped in dry ice and should immediately be thawed or stored in liquid nitrogen upon receipt. Do not use a -80°C freezer for long term storage.

Supplied As: Each vial contains 2 x 106 cells in 1 ml of cell freezing medium (BPS Bioscience, #79796)

Uniprot: Q96RD9

Warnings: Avoid freeze/thaw cycles.

Biosafety Level: BSL-1
More Information
SKU BPS78378
Manufacturer BPS Bioscience
Manufacturer SKU 78378
Green Labware No
Package Unit 2 vials
Quantity Unit PAK
Host Human
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