Product Type: Inhibitor
CAS No.: 72509-76-3
MolecularFormula: C18H19Cl2NO4
Molecular Weight: 384,25
Source: Synthetic
Purity: >98% (TLC); NMR (Conforms)
Solubility: Soluble to 100 mM in ethanol and to 100 mM in DMSO
Appearance: Light Yellow Solid
PubChem CID: 3333
Scientific Background: Felodipine is an L-type Ca2+ channel blocker (1). In isolated rat ventricular myocytes, using a whole-cell patch-clamp technique, it displays a Ki of 11 nM (2). It is a clinically useful antihypertensive agent (3) which attenuates the hypertrophic effect of cyclosporine on transplanted hearts (4).
References: 1. Furakawa T., et al. (2005) J Cardiovasc. Pharmacol. 45(3): 241-246.2. Zahradnikova Z., Minarovic I., Zahradnik I. (2007) J Pharmacol Exp. Ther. 322(2): 638-645.3. Manzo B.A., Matalka M.S., Ravnan S.L. (2003) Pharmacotherapy. 23(11): 1508-1512.4. Schwitter J., et al. (1999) J Heart Lung Transplant. 18(10): 1003-1013.
Field of Use: Not for use in humans. Not for use in diagnostics or therapeutics. For in vitro research use only.
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