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Applications: Useful for studying enzyme kinetics and screening small molecular inhibitors for drug discovery and HTS applications.
Background: FGFR2 (Fibroblast Growth Factor Receptor 2) is a member of a family of tyrosine kinases involved in many pathways that play a significant role in cancer. Amplification or activation of FGFR2 has been reported in breast and gastric cancers, while FGFR2 mutations have been observed in endometrial and breast cancers. Mutations in FGFR2 are also associated with bone development disorders including Pfeiffer Syndrome and Crouzon Syndrome.
Description: The FGFR2 Assay Kit is designed to measure FGFR2 activity for screening and profiling applications using Kinase-Glo® MAX as a detection reagent.
Storage Stability: Up to 6 months when stored as recommended.
Supplied As: The FGFR2 Assay Kit comes in a convenient 96-well format, with enough purified recombinant FGFR2, Protein Tyrosine Kinase Substrate (Poly-Glu,Tyr 4:1), ATP, and kinase assay buffer for 96 enzyme reactions.
Biosafety Level: Not applicable (BSL-1)
References: 1. Rutland, P., et al. 1995. "Identical mutations in the FGFR2 gene cause both Pfeiffer and Crouzon syndrome phenotypes." Nature Genetics 9(2): 173.
2. Xie, L., et al. 2013. "FGFR2 gene amplification in gastric cancer predicts sensitivity to the selective FGFR inhibitor AZD4547." Clinical Cancer Research 9(2): 2572-2583.
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