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Background: FGFR3, also known as fibroblast growth factor receptor 3 or CD333, is a transmembrane tyrosine kinase receptor which belongs to the fibroblast growth factor receptor family involved in osteogenesis and bone maintenance. It has a restricted pattern of expression and is found in the brain, kidneys, cartilage and intestine. Mutations in FGFR3 can result in achondroplasia, hypochondroplasia, Muenke syndrome, glioblastoma and urothelial carcinoma. Inhibitors of FGFR3 show promise for cancer therapy, with pemigatinib approved in 2020 for the treatment of metastatic cholangiocarcinoma.
Description: Recombinant human FGFR3 (fibroblast growth factor receptor 3, also known as CD333), encompassing amino acids 23-375 corresponding to the extracellular portion of the receptor. This construct contains a C-terminal Fc domain followed by an Avi-Tag™. This protein has a Factor Xa cleavage site prior to the Fc domain. This protein was affinity purified.
Format: Aqueous buffer solution.
Formulation: 8 mM phosphate, pH 7.4, 110 mM NaCl, 2.2 mM KCl, and 20% glycerol
Genbank: NM_000142.5
Host Cell Line: HEK293
Purity: ≥90%
Storage Stability: At least 6 months at -80°C.
Tags: C-terminal Avi-Tag™
Uniprot: P11362
Warnings: Avoid freeze/thaw cycles
Biosafety Level: Not applicable (BSL-1)
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