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Applications: Useful for studying enzyme kinetics and screening small molecular inhibitors for drug discovery and HTS applications.
Description: The FGFR3 (L496V) Assay Kit is designed to measure FGFR3 (L496V) activity for screening and profiling applications using Kinase-Glo® MAX as a detection reagent.
Storage Stability: Up to 6 months when stored as recommended.
Supplied As: The FGFR3 (L496V) Assay Kit comes in a convenient 96-well format, with enough purified recombinant FGFR3 (L496V), Protein Tyrosine Kinase Substrate (PolyGlu,Tyr 4:1), ATP, and kinase assay buffer for 96 enzyme reactions.
Warnings: Avoid multiple freeze/thaw cycles.
Biosafety Level: Not applicable (BSL-1)
References: 1. Cappellen, D.,et al. (1999) "Frequent activating mutations of FGFR3 in human bladder and cervix carcinomas." Nature Genetics 23(1): 18. 2. Billerey, C., et al. (2001) "Frequent FGFR3 mutations in papillary non-invasive bladder (pTa) tumors." Amer. J. Pathology 158(6): 1955-1959.
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