Product Type: Inhibitor
CAS No.: 104987-11-3
MolecularFormula: C44H69HO12
Molecular Weight: 804
Source: Synthetic
Purity: >98%
Solubility: May be dissolved in DMSO (50 mg/mL) or ethanol (50mg/mL)
Appearance: White powder
PubChem CID: 445643
Scientific Background: FK506 or Fujimycin or Tacrolimus, is an immunosuppressant. It is mainly used after allogeneic organ transplants, but can also be used topically in the treatment of eczema, uveitis and vitiligo (1). It is a macrolide that prevents the dephosphorylation of NF-AT. It reduces peptidyl-prolyl isomerase activity by binding to FKBP12 creating a new complex that interacts with and inhibits calcineurin (2, 3).
References: 1. Nanette B., et al. (2004) J Am Acad Derm. 51(5): 760-766.2. Ganong W.F., Review of Medical Physiology (22nd ed.) Lange Medical Books. P.5303. Liu J. Lane W., Friedman J, Weissman I and Schreiber S. (1991) Cell. 66(4): 807-815
Field of Use: Not for use in humans. Not for use in diagnostics or therapeutics. For in vitro research use only.
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