Clone Name: GT1281
Application Note: WB: 1:500 - 1:2000. *Optimal dilutions/concentrations should be determined by the researcher.Not tested in other applications.
Calculated MW: 12
Form: Liquid
Buffer (with preservative): PBS, 0.05% BSA, 50% Glycerol, 0.02% Sodium azide.
Concentration: 0.85 mg/ml (Please refer to the vial label for the specific concentration.)
Background: The protein encoded by this gene is a member of the immunophilin protein family, which play a role in immunoregulation and basic cellular processes involving protein folding and trafficking. The protein is a cis-trans prolyl isomerase that binds the immunosuppressants FK506 and rapamycin. It interacts with several intracellular signal transduction proteins including type I TGF-beta receptor. It also interacts with multiple intracellular calcium release channels, and coordinates multi-protein complex formation of the tetrameric skeletal muscle ryanodine receptor. In mouse, deletion of this homologous gene causes congenital heart disorder known as noncompaction of left ventricular myocardium. Multiple alternatively spliced variants, encoding the same protein, have been identified. The human genome contains five pseudogenes related to this gene, at least one of which is transcribed. [provided by RefSeq, Sep 2008]
Uniprot ID: P62942
Antigen Species: Human
Immunogen: A synthesized peptide derived from human FKBP12.
Purification: Purified by affinity chromatography
Conjugation: Unconjugated
Full Name: FKBP prolyl isomerase 1A
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