Fluorofenidone, CAS 848353-85-5

Fluorofenidone, CAS 848353-85-5
SKU
CAY39651-5
Packaging Unit
5 mg
Manufacturer
Cayman Chemical

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Formulation: A solid

Formal Name: 1-(3-fluorophenyl)-5-methyl-2(1H)-pyridinone

Purity: ≥98%

Formula Markup: C12H10FNO

Formula Weight: 203,2

Shelf life (days): 1460

CAS Number: 848353-85-5

Notes: Fluorofenidone is an antifibrotic agent and a derivative of pirfenidone (Item No. 13986).{72243,72244} It inhibits angiotensin II-induced increases in TGF-β1 secretion and reactive oxygen species (ROS) production, as well as TGF-β1-induced production of collagen I, in NRK-52E rat proximal tubular epithelial cells when used at a concentration of 8 mM.{72243} Fluorofenidone (500 mg/kg) decreases disease severity and the renal levels of collagen I, collagen III, and connective tissue growth factor (CTGF) in a rat model of obstructive nephropathy induced by unilateral ureteral obstruction.{72244} Fluorofenidone also increases survival in a mouse model of LPS-induced endotoxemia when administered at a dose of 200 mg/kg.{72245}
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SKU CAY39651-5
Manufacturer Cayman Chemical
Manufacturer SKU 39651-5
Package Unit 5 mg
Quantity Unit STK
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