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Applications: Great for studying enzyme kinetics and HTS applications.
Background: SHP1 (also known as PTPN6) is preferentially expressed in a variety of hematopoietic cells, and is an early response gene in lymphokine-stimulated cells. The noncatalytic N-terminus of this phosphatase can interact with MAP kinases and negatively regulates ERK2 and p38 MAP-kinases activity. The PTPN6 is involved in the regulation of T cell antigen receptor (TCR) signaling, which is thought to function through dephosphorylating molecules related to the MAP kinase pathway.
Description: The Fluorogenic SHP1 Assay Kit is designed to measure SHP1 activity for screening and profiling applications, in a homogeneous assay with no timeconsuming washing steps. This kit is developed to identify inhibitors of the regulatory region of SHP1.
Storage Stability: One year from date of receipt when stored as directed.
Supplied As: The SHP1 assay kit comes in a convenient 96-well format, with purified SHP1 enzyme, fluorogenic substrate, and PTP assay buffer for 100 enzyme reactions.
Warnings: Avoid freeze/thaw cycles.
Biosafety Level: Not applicable (BSL-1)
References: Gee, K.R., et al., Anal Biochem, 1999 Aug 15; 273(1):41-8. Kilgore, N.E., et al., J. Immunol. 2003, 170:4891-4895. Duchesne, C., et al. J. Biol. Chem 2003, 278:14274-14283.
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