Product Type: Activator
CAS No.: 66575-29-9
MolecularFormula: C22H34O7
Molecular Weight: 410,51
Source: Synthetic
Purity: >99%
Solubility: Soluble to 100 mM in DMSO, and to 10 mM in ethanol
Appearance: White Solid
PubChem CID: 47936
Scientific Background: Forskolin resensitizes cell receptors by activating adenyl cyclase, and increasing the intracellular levels of cAMP (1). Medically forskolin provides a route to inhibition of colon cancer cell growth and survival (2). It is also a vasodilator, may be helpful in controlling the cause of glaucoma (3), reduces urinary tract infections, and may help to increase the skin's natural resistance to burning under UV light (1).
References: 1. Passeron T., Namiki T., Passeron H.J., Le Pape E., and Hearing V.J. (2009) J Invest Dermatol. 129(1): 162-166.2. McEwan D.G., Brunton V.G., Baillie G.S., Leslie N.R., Houslay M.D., and Frame M.C. (2007) Cancer Research. 67(11).3. Pescosolido N., and Librando A. (2010) Clin Ter. 161(3): e81-5.
Field of Use: Not for use in humans. Not for use in diagnostics or therapeutics. For in vitro research use only.
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