Product Type: Agonist
CAS No.: 162359-56-0
MolecularFormula: C19H34ClNO2
Molecular Weight: 343,9
Source: Synthetic
Purity: >98% (TLC); NMR (Conforms)
Solubility: Soluble to 100 mg/ml in DMSO or to 40 mg/ml in ethanol (warmed)
Appearance: White solid
PubChem CID: 107969
Scientific Background: FTY720 is a potent sphingosine 1-phosphate receptors (S1P) agonist once it is phosphorylated by sphingosine kinase. This causes lymphocytes to be sequestered in lymph nodes, which also makes FTY720 an immune modulating drug for multiple sclerosis. It has been shown to stimulate neuronal gene expression, axonal growth and regeneration (3). And recently FTY720 has also been shown to reduce α-Synuclein pathology in parkinsonian GM2+/- Mice (4).
References: 1. Wolf A., et al. (2009) J Immunol. 183(6): 3751-60.2. Brinkmann V., et al. (2002) J Biol Chem. 277(24): 21453-7. 3. Anastasiadou S., and Knoll B. (2016) Exp. Neurol. 279: 243-260. 4. Vidal-Martinez G., at al. (2019) Neuroscience. 411: 1-10.
Field of Use: Not for use in humans. Not for use in diagnostics or therapeutics. For in vitro research use only.
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