Fumagillol, CAS 108102-51-8

Formulation: A solid

Formal Name: (3R,4S,5S,6R)-5-methoxy-4-[(2R,3R)-2-methyl-3-(3-methyl-2-buten-1-yl)-2-oxiranyl]-1-oxaspiro[2.5]octan-6-ol

Purity: ≥95%

Formula Markup: C16H26O4

Formula Weight: 282,4

Shelf life (days): 1460

CAS Number: 108102-51-8

Notes: Fumagillol is a sesquiterpenoid that has been found in P. jensenii and has diverse biological activities.{69484,69485,69486,69487} It is an inhibitor of methionyl aminopeptidase 2 (METAP2; IC50 = 230 nM for the human enzyme).{69484} Fumagillol is active against the parasite G. lamblia (IC50 = 3.4 µM).{69485} It reduces the proliferation of isolated calf pulmonary artery endothelial cells (IC50 = 8.09 µM) and human umbilical vein endothelial cells (HUVECs; EC50 = 49 nM).{69486,69484} Fumagillol inhibits the proliferation of isolated mouse splenocytes in a mixed lymphocyte reaction (IC50 = 250 nM).{69487}

• SKU: CAY39766-10
• Manufacturer: Cayman Chemical
• Manufacturer SKU: 39766-10
• Green Labware: No
• Package Unit: 10 mg
• Quantity Unit: STK