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Applications: Useful for studying enzyme kinetics and screening small molecular inhibitors for drug discovery and HTS applications.
Background: FYN is member of the SRC tyrosine kinase oncogene family. It plays a role in various forms of cancer and is a notable molecular target in prostate cancer. Fyn interacts with both amyloid-beta (Aβ) and tau, suggesting that inhibition of FYN has potential as a therapy for Alzheimer's disease.
Description: The FYN Assay Kit is designed to measure FYN activity for screening and profiling applications using Kinase-Glo® MAX as a detection reagent.
Storage Stability: Up to 6 months when stored as recommended.
Supplied As: The FYN Assay Kit comes in a convenient 96-well format, with enough purified FYN, Protein Tyrosine Kinase Substrate (Poly-Glu,Tyr 4:1), ATP, and kinase assay buffer for 96 enzyme reactions.
Warnings: Avoid freeze/thaw cycles.
Biosafety Level: Not applicable (BSL-1)
References: 1. Resh, M.D. "Fyn, a Src family tyrosine kinase." Int. J. Biochem. Cell. Biol. 30.11 (1998): 1159-1162.
2. Umemori, H., et al. "Initial events of myelination involve Fyn tyrosine kinase signaling." Nature 367.6463 (1994): 572-576.
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