Formulation: A neat oil
Formal Name: N,N′-(dithiodi-2,1-ethanediyl)bis-1H-indole-3-ethanamine
Purity: ≥95%
Formula Markup: C24H30N4S2
Formula Weight: 438,6
Shelf life (days): 1460
CAS Number: 421581-52-4
Notes: G6PD activator AG1 is an activator of glucose-6-phosphate dehydrogenase (G6PDH; EC50 = 3.4 µM for G6PDHR459L).{68590} It selectively induces the dimerization of G6PDHR459L over 6-phosphogluconate dehydrogenase (6PGD), GAPDH, aldehyde dehydrogenase 2 (ALDH2), and ALDH3A1. G6PD activator AG1 decreases the levels of reactive oxygen species (ROS) in, and increases the viability of, primary human lymphocytes isolated from a patient carrying the G6PDHR459L mutation. It inhibits hemolysis induced by chloroquine (Item No. 14194) or diamide in isolated human erythrocytes when used at a concentration of 5 µM. G6PD activator AG1 (1 µM) decreases chloroquine-induced pericardial edema in zebrafish embryos. It decreases tumor volume and weight and increases survival in an NCI H226 lung mesothelioma mouse xenograft model when administered at a dose of 40 mg/kg.{68591}
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