Target: GABA A Receptor
Conjugate: ATTO 390
Product Type: Monoclonal
Clone Number: N95/35 (Formerly sold as S95-35)
Immunogen: Fusion protein amino acids 355-394 of human GABA-A-R-Alpha1
Swiss-Prot: P14867
Purification: Protein G Purified
Storage Buffer: PBS, 50% glycerol, 0.1% azide *Storage buffer may change when conjugated
Concentration: 1 mg/ml
Specificity: Detects ~55kDa. No cross-reactivity against GABA-A-R-Alpha 2 or –Alpha3.
Cellular Localization: Cell Membrane,Cell Junction,Synapse,Postsynaptic Cell Membrane
Scientific Background: The GABA-A receptor is a member of the superfamily of fast acting ligand-gated ion channels. The individual subunits of these receptors have similar sequences and structural features (1). GABA-A receptors are the major fast inhibitory neurotransmitter gated ion channels in the brain (2).
References: 1. Bracamontes J.R. and Steinbach J.H. (2008) J Bio Chem. 283: 26128-26136.2. Macdonald R.L., Olsen R.W. (1993) Annu Rev Neurosci. 17: 569-602.
Field of Use: Not for use in humans. Not for use in diagnostics or therapeutics. For in vitro research use only.
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