Clone Name: HL1187
Light Chain: Kappa
Application Note: WB: 1:500-1:3000. *Optimal dilutions/concentrations should be determined by the researcher.Not tested in other applications.
Calculated MW: 65
Specificity/Sensitivity: This antibody is specific for GAD65 protein, and it does not cross-react with GAD67 protein.
Form: Liquid
Buffer (with preservative): PBS, no preservative.
Concentration: 1 mg/ml (Please refer to the vial label for the specific concentration.)
Background: This gene encodes one of several forms of glutamic acid decarboxylase, identified as a major autoantigen in insulin-dependent diabetes. The enzyme encoded is responsible for catalyzing the production of gamma-aminobutyric acid from L-glutamic acid. A pathogenic role for this enzyme has been identified in the human pancreas since it has been identified as an autoantibody and an autoreactive T cell target in insulin-dependent diabetes. This gene may also play a role in the stiff man syndrome. Alternative splicing results in multiple transcript variants that encode the same protein. [provided by RefSeq, Oct 2008]
Uniprot ID: Q05329
Antigen Species: Human
Immunogen: Recombinant protein encompassing a sequence within the C-terminus region of human GAD65. The exact sequence is proprietary.
Purification: Affinity purified by Protein A.
Conjugation: Unconjugated
Full Name: glutamate decarboxylase 2
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