Solubility: Soluble in water (12 mg/ml) or in DMSO (10 mg/ml)
Appearance: White powder
PubChem CID: 121587
Scientific Background: Galantamine hydrobromide is a long-acting, active acetylcholinesterase inhibitor (IC50 = 410 nM) and allosteric potentiator at neuronal nicotinic ACh receptors. It prevents β-amyloid-induced apoptosis in SH-SY5Y. Long-term administration in a mouse model of Alzheimer's disease reduces amyloid precursor protein deposition and neurodegeneration in these mice.
Field of Use: Not for use in humans. Not for use in diagnostics or therapeutics. For in vitro research use only.