Application Note: WB: 1:300-1:5000. FACS: 1:20-1:100. *Optimal dilutions/concentrations should be determined by the researcher.Not tested in other applications.
Calculated MW: 187
Specificity/Sensitivity: This phosphorylation site is homologous to Thr898 in Mouse and Thr899 in Rat.
Form: Liquid
Buffer (with preservative): 0.01M TBS pH 7.4, 1% BSA, 50% Glycerol, 0.03% Proclin300.
Concentration: 1 mg/ml (Please refer to the vial label for the specific concentration.)
Background: This gene encodes a member of a family of kinases that phosphorylate the alpha subunit of eukaryotic translation initiation factor-2 (EIF2), resulting in the downregulaton of protein synthesis. The encoded protein responds to amino acid deprivation by binding uncharged transfer RNAs. It may also be activated by glucose deprivation and viral infection. Mutations in this gene have been found in individuals suffering from autosomal recessive pulmonary venoocclusive-disease-2. [provided by RefSeq, Mar 2014]
Uniprot ID: Q9P2K8
Antigen Species: Human
Immunogen: KLH conjugated synthetic phosphopeptide derived from human GCN2 around the phosphorylation site of Thr899.
Purification: Protein A purified
Conjugation: Unconjugated
Full Name: eukaryotic translation initiation factor 2 alpha kinase 4
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