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Applications: Useful for the study of enzyme kinetics, screening inhibitors, and selectivity profiling.
Biological Activity: Geldanamycin strongly inhibited Hsp90 protein as shown through inhibited Plasmodium falciparum growth in human erythrocyte culture with an IC50 of 20 nM.
CAS Number: 30562-34-6
Concentration: 10 mM
Description: Geldanamycin is an antibiotic and a potent antitumor compound. It inhibits pp60src tyrosine kinase, and it also binds specifically to heat shock protein Hsp90 and its GP96 homologue. It is known to inhibit protein maturation.
Format: DMSO solution
Purity: ≥95% by HPLC.
Solubility: Soluble in anhydrous DMSO at 100 mg/ml. Poorly soluble in methanol. Ethanol and water are not recommended for stock solutions. The maximum water solubility is estimated to be ~ 20 -50 µM.
Storage Stability: Store at or below -20°C. Solid form is stable at least 12 months from date of receipt, when stored as directed. Geldanamycin is unstable in water and ethanol. Does not react with DMSO, but DMSO can contain moisture from the air and/or small amounts of DMSO degradation products that might react. Keep DMSO stock solutions out of contact with air. Do not store aqueous solutions for more than one day.
Warnings: Protect from air and moisture.
Biosafety Level: Not applicable (BSL-1)
References: 1. Whitesell, L. and Cook, P. Mol. Endocr. 10: 705 - 712 (1996)
2. Rajinder, K., et al., Malaria Journal 2:30 (2003)
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