Product Type: Inhibitor
CAS No.: 446-72-0
MolecularFormula: C15H10O5
Molecular Weight: 270,2
Source: Synthetic
Purity: ≥98% (HPLC)
Solubility: Soluble in DMSO (30 mg/ml), 100% ethanol (4 mg/ml) or dilute aqueous base; insoluble in water
Appearance: Creamy off-white solid
PubChem CID: 5280961
Scientific Background: Genistein has a wide range of biological actions. It is an inhibitor of tyrosine protein kinase, including epidermal growth factor receptor kinase. It also inhibits DNA topoisomerase and α-glucosidase. It produces cell cycle arrest and apoptosis, and inhibits endocytosis, as well as, inhibits insulin-induced glucose uptake in adipocytes.
References: 1. Akiyama T., et al. (1987) J Biol. Chem. 262(12): 5592–5595.2. Bazuine M., van den Broek P.J.A., & Maassen J. A. (2005) Biochem. Biophys. Res. Comm. 326(2): 511–514. 3. Linassier C., Pierre M., Le Pecq J.B., & Pierre J. (1990) Biochem. Pharm. 39(1): 187–193.4. Dean N.M., Kanemitsu M., & Boynton A.L. (1989) Biochem. Biophys. Res. Comm. 165(2): 795–801.
Field of Use: Not for use in humans. Not for use in diagnostics or therapeutics. For in vitro research use only.
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