Product Description: Genz-123346 (free base) is an inhibitor of GL1 synthase that blocks the conversion of ceramide to GL1; inhibits GM1 with IC50 value of 14 nM.
Applications: Cancer-Kinase/protease
Formula: C24H38N2O4
Citations: Faculty of Life Sciences, University College London. 2019 Oct./Front Pharmacol. 2024 Oct 1:15:1409625./PeerJ. September 14, 2021./Am J Respir Crit Care Med. 2019 Nov 1;200(9):1113-1125.
References: [1]Zhao H, et al. Inhibiting glycosphingolipid synthesis improves glycemic control and insulin sensitivity in animal models of type 2 diabetes. Diabetes. 2007 May;56(5):1210-8./[2]Chai L, et al. The chemosensitizing activity of inhibitors of glucosylceramide synthase is mediated primarily through modulation of P-gp function. Int J Oncol. 2011 Mar;38(3):701-11./[3]Shen W, et al. Inhibition of glucosylceramide synthase stimulates autophagy flux in neurons. J Neurochem. 2014 Jun;129(5):884-94/[4]Natoli TA, et al. Inhibition of glucosylceramide accumulation results in effective blockade of polycystic kidney disease in mouse models. Nat Med. 2010 Jul;16(7):788-92.
CAS Number: 491833-30-8
Molecular Weight: 418.57
Compound Purity: 99.80
Research Area: Metabolic Disease; Cancer
Solubility: DMSO : ≥ 100 mg/mL
Target: Others
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