Formulation: A solid
Formal Name: 2-[[4-[(3β)-cholest-5-en-3-yloxy]-1,4-dioxobutyl]amino]-2-deoxy-D-glucopyranose
Purity: ≥95%
Formula Markup: C37H61NO8
Formula Weight: 647,9
Shelf life (days): 730
CAS Number: 1257309-90-2
Notes: Glucosamine cholesterol is a glucosamine-based lipid conjugate that has been used in the formation of lipid nanoparticles (LNPs).{72078} It forms a stable, ordered bilayer with the glucosamine moiety facing outward to facilitate recognition by glucose transporter 1 (GLUT1) on cells. LNPs containing glucosamine cholesterol and encapsulating ceramide induce apoptosis in hypoxic human A549 lung carcinoma cells and A549-derived side population cells, also known as cancer stem cells (CSCs), but not hypoxic mouse L-929 fibroblasts. LNPs containing glucosamine cholesterol and encapsulating paclitaxel (Item No. 10461) and carboplatin (Item No. 13112) reduce tumor volume and increase the number of tumor-associated cytotoxic T cells in an LL/2 murine lung carcinoma model.
English
Deutsch
