Target: NR2B
Conjugate: RPE
Product Type: Monoclonal
Clone Number: S59
Immunogen: Fusion protein amino acids 20-271 (extracellular N-terminus) of rat NR2B
Swiss-Prot: Q00960
Purification: Protein G Purified
Storage Buffer: PBS pH7.4, 50% glycerol, 0.09% sodium azide *Storage buffer may change when conjugated
Concentration: 1 mg/ml
Specificity: Detects ~166kDa. No cross-reactivity against NR2A.
Cellular Localization: Cell Membrane,Cell Junction,Synapse,Postsynaptic Cell Membrane
Scientific Background: NR2B containing receptors have been implicated in synaptic plasticity, memory formation and pain modulation (1). Studies suggest that the NR2B subunit of glutamate receptors may be potential targets for relieving pain; NR2B may be a probable target for anti-nociceptive drugs, and may also be useful as analgesics (2).
References: 1. Zhuo M. (2009) Mol Brain. 2(1): 42. Gurwitz D, and Weizman A. (2002) Drug Discovery Today, 7(7): 403-406.
Field of Use: Not for use in humans. Not for use in diagnostics or therapeutics. For in vitro research use only.
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