Glutaminase C Inhibitor 11

Formulation: A solid

Formal Name: (R)-2-(3-phenoxyphenyl)-N-(5-((1-(pyridazin-3-yl)pyrrolidin-3-yl)amino)-1,3,4-thiadiazol-2-yl)acetamide

Purity: ≥95%

Formula Markup: C24H23N7O2S

Formula Weight: 473,6

Shelf life (days): 1095

Notes: Glutaminase C inhibitor 11 is an inhibitor of glutaminase C (GAC).{65908} It inhibits GAC enzyme activity (EC50 = 10.64 nM) and reduces the viability of A549 non-small cell lung cancer (NSCLC) cells (IC50 = 4.025 nM). Glutaminase C inhibitor 11 (0.1 and 1 µM) reduces colony formation by, and intracellular glutamate levels in, A549 cells. In vivo, glutaminase C inhibitor 11 (100 mg/kg) reduces tumor growth in an A549 mouse xenograft model.

• SKU: CAY39883-5
• Manufacturer: Cayman Chemical
• Manufacturer SKU: 39883-5
• Green Labware: No
• Package Unit: 5 mg
• Quantity Unit: STK