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Applications: Development and optimization of Glycophorin A-binding antibodies or related peptides; Assay Development
Background: Glycophorin A (GYPA, also known as CD235a) is a sialoglycoprotein and a major intrinsic membrane protein on the surface of human erythrocytes. GYPA plays an important role in the prevention of red cell aggregation in the circulatory system. The Glycophorin A gene contains some antigenic alleles of the MNS blood grouping system for which 40 known variants exist. Several of these antigenic variants have implications for pathogen interaction. For example, the Wright b antigen in the helical region of Glycophorin A acts as a receptor for the malaria parasite Plasmodium falciparum. Other variations such as the Mur phenotype causes hemolytic transfusion reaction (HTR) and hemolytic disease in the newborn fetus (HDFN). Glycophorin A is one of the most abundant integral proteins of the red cell membrane, and its genetic sequence varies within a population; therefore, it may also support applications in forensic science.
Description: Recombinant clonal CHO-K1 stable cell line constitutively expressing full-length human Glycophorin A (GYPA, transcript variant 1, Seq ID: NM_002099.8). The surface expression of Glycophorin A was validated by flow cytometry.
Host Cell Line: CHO
Mycoplasma Testing: The cell line has been screened to confirm the absence of Mycoplasma species.
Storage Stability: Cells are shipped in dry ice and should immediately be thawed or stored in liquid nitrogen upon receipt. Do not use a -80°C freezer for long-term storage.
Supplied As: Each vial contains 2 x 106 cells in 1 ml of cell freezing medium (BPS Bioscience #79796)
Uniprot: P02724
Warnings: Avoid freeze/thaw cycles.
Biosafety Level: BSL-1
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