GMX1777, CAS 432037-57-5

Formulation: A solid

Formal Name: 4-[[[[6-(4-chlorophenoxy)hexyl]imino](cyanoamino)methyl]amino]-1-(3-oxo-2,4,7,10,13,16-hexaoxaheptadec-1-yl)-pyridinium, monochloride

Purity: ≥98%

Formula Markup: C30H43ClN5O8 • Cl

Formula Weight: 672,6

Shelf life (days): 1460

CAS Number: 432037-57-5

Notes: GMX1777 is a prodrug form of the nicotinamide phosphoribosyltransferase (Nampt) inhibitor CHS-828 (Item No. 11021).{68386} Intravenous administration of GMX1777 (75 and 150 mg/kg) reduces NAD+ levels in tumors, but not muscle tissue, in a DMS 273 lung cancer mouse xenograft model. GMX1777 (50 mg/kg per day), in combination with radiation, decreases tumor diameter and microvessel density in C666-1 nasopharyngeal and FaDu head and neck squamous cell carcinoma (HNSCC) mouse xenograft models.{68387}

• SKU: CAY38798-5
• Manufacturer: Cayman Chemical
• Manufacturer SKU: 38798-5
• Package Unit: 5 mg
• Quantity Unit: STK
• Application: Reinstoffe